Phosphatidylserine

Phosphatidylserine is a glycerol-based phospholipid. It is found naturally within the brain, where it is a major component of cortical cell membranes (1). Here, it plays a key role in synaptic neurotransmission via several mechanisms, including a direct effect on cell transport mechanisms and modulation of neurotransmitters such as the AMPA glutamate receptor (2). As the concentration of phosphatidylserine decreases with advancing age (3,4), supplementation may preserve some of the benefits of phosphatidylserine as we age. These benefits are potentially wide-ranging and include increases in focus, memory and relaxation.

Several human studies have highlighted the potential of phosphatidylserine as a memory booster in aging populations. In a double-blind cross-over study, for example, eight-week supplementation with phosphatidylserine in early Alzheimer’s disease showed significant increases in clinical global improvement ratings, and electroencephalogram (EEG) changes more akin to the non-diseased brain, compared to placebo (5).

In younger populations, the focus-enhancing effects of phosphatidylserine have shown promise. A randomised double-blind placebo-controlled trial on children with symptoms of attention deficit showed that two-month supplementation with 200mg phosphatidylserine resulted in significant improvements in inattention compared to placebo (6). And in a study of similar design, 42 day supplementation in young golfers significantly increased the number of good ball flights during tee-off (7).

Studies have also emerged that suggest phosphatidylserine may have relaxing properties. A test-re-test design study showed EEG evidence of a more relaxed brain state during induced stress when comparing 42 day supplementation to placebo (8).

The research above highlights the potential of phosphatidylserine as a versatile nootropic. It has been shown to be a safe supplement to ingest, with soy-based intake of up to 600mg daily raising no safety concerns in humans (9).

Nootropics for:

Memory, Focus, Relaxation

Mechanism of Action:

Component of brain cell membranes

Suggested dose:

100 mg one to three times per day

Good to know:

A versatile and naturally occuring supplement